Journal of Conservative Dentistry

REVIEW ARTICLE
Year
: 2020  |  Volume : 23  |  Issue : 6  |  Page : 544--549

Insight into status of dental caries vaccination: A review


Gayathri Cherukuri1, Chandrasekhar Veeramachaneni2, GV Rao3, Venkat Baghirath Pacha1, Sudheer B Balla4 
1 Department of Oral and Maxillofacial Pathology, Panineeya Mahavidyalaya Institute of Dental Sciences, Hyderabad, India
2 Department of Conservative and Endodontics, Malla Reddy Dental College for Women, Hyderabad, India
3 Department of Oral and Maxillofacial Pathology, Mamata Dental College, Khammam, Telangana, India
4 Department of Forensic Odontology, Panineeya Mahavidyalaya Institute of Dental Sciences, Hyderabad, India

Correspondence Address:
Dr. Chandrasekhar Veeramachaneni
Department of Conservative and Endodontics, Malla Reddy Dental College for Women, Hyderabad, Telangana
India

Despite advances in the 21st century, dental caries still remains to be one of the most common infectious diseases. Its prevalence was confirmed by the World Health Organization and affirms dental caries as a major health problem in all over the world. Even though the process of tooth decay is multifactorial, the oral bacteria, mutans streptococci, such as Streptococcus mutans and Streptococcus sobrinus, are considered to be causative agents of dental caries in human. Numerous studies carried out on animals and various categories of vaccines were developed such as whole cell vaccine, subunit vaccine, and synthetic peptides. Irrespective of success from active and passive immunization based on animal trials, it is the phenomenon of human heart reactivity that limited the applicability of these trials in humans. Continuous efforts are being made to overcome these limitations and for further success in human trials. With the advent of various antibodies against antigens of mutans streptococci, local passive immunization has become the safer approach in humans against the colonization of bacteria and caries induction. This review provided insight into epidemiology, active and passive immunization in both animal and human trials, as well as the prospects of caries vaccination.a


How to cite this article:
Cherukuri G, Veeramachaneni C, Rao G V, Pacha VB, Balla SB. Insight into status of dental caries vaccination: A review.J Conserv Dent 2020;23:544-549


How to cite this URL:
Cherukuri G, Veeramachaneni C, Rao G V, Pacha VB, Balla SB. Insight into status of dental caries vaccination: A review. J Conserv Dent [serial online] 2020 [cited 2021 Dec 1 ];23:544-549
Available from: https://www.jcd.org.in/article.asp?issn=0972-0707;year=2020;volume=23;issue=6;spage=544;epage=549;aulast=Cherukuri;type=0