Journal of Conservative Dentistry
Home About us Editorial Board Instructions Submission Subscribe Advertise Contact e-Alerts Login 
Users Online: 516
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size
Year : 2019  |  Volume : 22  |  Issue : 1  |  Page : 17-22

Cellular interaction and antibacterial efficacy of two hydraulic calcium silicate-based cements: Cell-dependent model

1 Department of Dental Biomaterials, Faculty of Oral and Dental Surgery, Zagazig University, Zagazig, Egypt
2 Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
3 Department of Oral Biology, Faculty of Oral and Dental Surgery, Zagazig University, Zagazig, Egypt

Correspondence Address:
Dr. Salma M Fathy
Department of Dental Biomaterials, Faculty of Oral and Dental Medicine, Zagazig University
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JCD.JCD_272_18

Rights and Permissions

Background: This study investigated cytotoxic probability, osteogenic potential, and antibacterial efficacy of two pulp-capping hydraulic calcium-silicate cements. Materials and Methods: For osteogenic potential and cytotoxicity evaluation, mesenchymal stem cells (MSCs) and materials disc-shaped specimens were used. Increase or decrease in a number of proliferating MSCs was calculated after three intervals. Alkaline phosphatase (ALP) levels in osteogenic media were normalized to the total protein content of cells and measured spectrophotometrically. Antibacterial efficiency through growth curves of Streptococcus mutans in direct contact with tested materials. Results: Biodentine showed the highest number of proliferating MSCs (278000.41 ± 4000.06, after 72 h) and the highest concentration of ALP after 12 days (209.26 ± 7.17 μU/μg protein). It showed the lowest slope (0.003 ± 0.0005) of S. mutans strains growth curves after 18 h. Conclusion: Biodentine proved a highly significant osteogenic ability and gave a significant reduction of S. mutans growth.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded142    
    Comments [Add]    

Recommend this journal