Journal of Conservative Dentistry
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ARTICLE
Year : 2006  |  Volume : 9  |  Issue : 2  |  Page : 78-80

Emerging role of the insulin like growth factors in pulp healing, reparative dentinogenesis and periodontal regeneration


Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Chennai, India

Correspondence Address:
Uma Sudhakar
Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Chennai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-0707.42362

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The role of Insulin like growth factors (IGF) in neoplastic transformation, in transversion of cell cycle during the growth and development by induction of enamel biomineralisation of the tooth and in periodontal development have been well documented in the past. However studies suggesting its usage in dental therapy have been limited. This review article hence, brings together various studies that have suggested its role as a therapeutic agent in dental pulp healing and reparative dentinogenesis along with periodontal regeneration. Positive results were achieved when IGF was combined with other therapeutic agents like platelet derived growth factor (PDGF) and calcium hydroxide in healing of apical perforations. When combined with heparin. IGF-l increased the expression of bone morphogenic protein 4 mRNA. Treatment with IGF-I inhibited DNA fragmentation in periodontal ligament fibroblasts. This article also includes background information on the IGF system and its mechanism of action.


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