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  Indian J Med Microbiol
 

Figure 1: (a) Pre-operative clinical picture (b) 15 mm &215; 16 mm &215; 16 mm gigantic lesion exposed along with root end resection being done (c) Combination of platelet rich fibrin (PRF) clot and hydroxyapatite crystals placed over the defect (d) 2 layers of PRF membrane placed covering the edge of the defect (e) post-operative clinical picture

Figure 1: (a) Pre-operative clinical picture (b) 15 mm &215; 16 mm &215; 16 mm gigantic lesion exposed along with root end resection being done (c) Combination of platelet rich fibrin (PRF) clot and hydroxyapatite crystals placed over the defect (d) 2 layers of PRF membrane placed covering the edge of the defect (e) post-operative clinical picture