Effect of two desensitizing agents on dentin hypersensitivity: A randomized split-mouth clinical trial
Angambakkam Rajasekaran PradeepKumar1, Venkatnagaraj Viswanath1, Kamna Singh2, Kuzhanchinathan Manigandan3, Haseena Begum Iqbal4, Anil Kishen5
1 Department of Conservative Dentistry and Endodontics, Thai Moogambigai Dental College and Hospital, Dr. MGR Educational and Research Institute (Deemed to be University) Chennai, India
2 Dental Research Institute, Faculty of Dentistry, 124 Edward Street, Toronto, Canada
3 Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai, Tamilnadu, India
4 Dental Clinic, Chennai, Tamilnadu, India
5 Dental Research Institute, Faculty of Dentistry, 124 Edward Street; Department of Dentistry, Mount Sinai Hospital, Sinai Health System, Toronto, Canada
Dr. Angambakkam Rajasekaran PradeepKumar
Department of Conservative Dentistry and Endodontics, Thai Moogambigai Dental College and Hospital, Dr. MGR Educational and Research Institute (Deemed to be University), Chennai - 600 095, Tamil Nadu
Source of Support: None, Conflict of Interest: None
Background: Clinical research is important to evaluate the effect of desensitizing agents.
Aims: This randomized clinical trial evaluated the immediate and 1 week desensitizing effect of two desensitizing agents Uno Topical Gel and Profluorid.
Materials and Methods: Thirtyfive patients with teeth presenting with dentin hypersensitivity were included in this clinical trial. Each quadrant in a patient was randomly assigned to one of two groups: Uno Topical Gel or Profluorid Varnish. A VAS score was used to assess tooth sensitivity at baseline, immediately after application of desensitizer and after 1 week. Additionally, 30 dentin discs were prepared, divided into Group 1(Control Group), Group 2 (Profluorid Varnish) and Group 3 (Uno Topical Gel) and examined using scanning electron microscopy (SEM) after 1hour and 24 hours to evaluate tubule occlusion.
Statistical Analysis: Clinical data were analysed using Friedman's test and Mann – Whitney U test. SEM data was analysed using Student's 2-sample t-test.
Results: Uno group was significantly better to evaporative stimuli immediately (P=0.01) after application. After 1 week, Uno group was significantly better to tactile (P=0.000) and evaporative (P=0.000) stimuli than Profluorid. SEM images showed that 1 hour after application, Uno and Profluorid demonstrated more than 90% and 80% dentin tubule occlusion respectively. At 24 hours, Uno and Profluorid demonstrated more than 50% and 60% dentin tubule occlusion respectively.
Conclusions: Uno Topical Gel was significantly better than Profluorid in reducing pain of dentin hypersensitivity due to tactile and evaporative stimuli after 1 week.