Journal of Conservative Dentistry
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Year : 2016  |  Volume : 19  |  Issue : 5  |  Page : 465-468

Capacity of a hydroxyapatite–lysozyme combination against Streptococcus mutans for the treatment of dentinal caries

Department of Restorative Dentistry, School of Dentistry, Pontifícia Universidade Católica de Campinas, Campinas, São Paulo, Brazil

Correspondence Address:
Sérgio Luiz Pinheiro
Rua Raul Gasparini, no 525 Bairro Panorama, Vinhedo, Sao Paulo 13280-000
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-0707.190026

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Background: One current strategy for the treatment of carious lesions is the use of biomaterials with antimicrobial activity. Aims: The aim of this study was to evaluate a combination of hydroxyapatite and lysozyme for the treatment of dentinal caries by measuring Streptococcus mutans counts before carious tissue sealing, and 24 h, 1 month, and 6 months after treatment. Materials and Methods: Forty permanent third molars were selected, and flat dentin surfaces were prepared. The teeth were exposed to a cariogenic challenge with S. mutans. After challenge, the dentinal caries were collected from five specimens. The remaining specimens were treated with a mixture of hydroxyapatite and lysozyme in sodium laureth sulfate and sealed with composite resin. S. mutans counts were obtained 24 h, 1 month, and 6 months after sealing. Statistical Analysis: The results were evaluated by descriptive statistics and Wilcoxon signed-rank test. Results: a significant reduction in S. mutans (CFU/mL) was observed in dentinal lesions 1 month after treatment with hydroxyapatite/lysozyme in sodium laureth sulfate (P = 0.0254). Comparison of S. mutans counts obtained 24 h, 1 month, and 6 months after treatment revealed reductions only at the 1-month time point (P = 0.0318). Conclusions: the combination of hydroxyapatite and lysozyme may be an alternative for reducing the S. mutans burden in dentinal caries.

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