Journal of Conservative Dentistry
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Year : 2011  |  Volume : 14  |  Issue : 2  |  Page : 160-163

The effect of 4% Lignocaine gel, 5% Amiloride HCl and 10% Chlorpromazine on E.faecalis

Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College, Chennai, India

Correspondence Address:
Udayakumar Jayasimha Raj
Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College, Alapakkam main road, Maduravoyal, Chennai-600 095
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-0707.82623

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Introduction : Thorough disinfection of the root canal system is essential for the success of root canal therapy. Enterococcus faecalis is the most frequently found species in persistent/secondary intracanal infection associated endodontic treatment failure. The aim of this study was to evaluate the disinfection of dentinal tubules using 10% Chlorpromazine, 4% Lignocaine gel, 5% Amiloride hydrochloride in comparison with 2% chlorhexidine gel. Materials and Methods : The antibacterial efficacy of the four medicaments against Enterococcus faecalis was assessed in vitro using extracted human first and second mandibular premolar teeth at the depths of 200 ΅m and 400 ΅m. Results : The overall percentage inhibition of bacterial growth was 100% with 2% chlorhexidine gel followed by 10% chlorpromazine (88.8%), 4% lignocaine gel (76.4%) and 5% amiloride hydrochloride (71.4%). Conclusion : 2% chlorhexidine gel was most effective against E. faecalis followed by the newer non- antibiotic medicament 10% chlorpromazine when compared to the other medicaments tested.

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